Biogenique Structurally Active-Orthogenic (SAO) technology
Vitamin B6 must be obtained from the diet and supplements because humans cannot synthesize it. There are three traditionally considered forms of vitamin B6: pyridoxal (PL), pyridoxine (PN), pyridoxamine (PM). The phosphate ester derivative pyridoxal 5’-phosphate (PLP) is the principal coenzyme form. SAO technology in Biogenique vitamin B-6 supplements stimulates the production of PLP in the human body, promoting the function of approximately 100 enzymes that catalyze essential chemical reactions. Our research says, pyridoxine deficiency in children principally affects the cognition (writing, learning and language skills), peripheral nerves, skin, mucous membranes, circulatory (blood cell) system and respiratory system.
SAO Analysis - Pyridoxine functions:
Nervous system function
In the brain, the synthesis of several neurotransmitters, enzymes and chemicals that carry signals from one nerve cell to another is catalyzed by a PLP-dependent enzyme. Vitamin B6 helps in production of hormones like serotonin, epinephrine and melatonin which influence our mood, appetite, body clock (sleep patterns) and sensitivity to pain.
Red blood cell formation
PLP functions as a coenzyme in the synthesis of heme, an iron-containing component of hemoglobin. Hemoglobin is found in red blood cells and is essential to transport oxygen throughout the body. PLP are able to bind to the hemoglobin molecule and affects its ability to pick up and release oxygen.
Niacin (vitamin B3) formation
The human requirement of another B vitamin, niacin, can be met in part by conversion of the essential amino acid, tryptophan, to niacin with the help of coenzyme PLP. Thus adequate vitamin B6 decreases the requirement for dietary niacin
Pyridoxine-dependent seizures in newborns can result from the use of high-dose pyridoxine in pregnant mothers or from autosomal recessive (genetic) pyridoxine dependency. Refractory seizures in newborns that are caused by pyridoxine dependence may be controlled quickly with intravenous administration of pyridoxine by a qualified healthcare provider.
Micronutrient status can affect cognitive function at all ages. Vitamin deficiencies could influence memory function and might contribute to age-associated cognitive impairment and dementia. Vitamin B6, comprising three chemically distinct compounds pyridoxal, pyridoxamine, and pyridoxine, is involved in the regulation of mental function and mood. Vitamin B6 is also an essential homocysteine re-methylation cofactor, and deficiency is associated with increase in blood homocysteine levels. Homocysteine is a risk factor for cerebrovascular disease and may also have directly toxic effects on neurons of the central nervous system. Neuropsychiatric disorders including seizures, migraine, chronic pain and depression have been linked to vitamin B6 deficiency.
Immune system health
Vitamin B6 is important for immune system function, such as for production of antibodies. Decreased production of immune system cells known as lymphocytes, as well as decreased production of an important immune system protein called interleukin-2, have been reported in vitamin B6 deficient individuals. Restoration of vitamin B6 status has resulted in normalization of lymphocyte proliferation and interleukin-2 production, suggesting that adequate vitamin B6 intake is important for optimal immune system function
One double-blind, placebo-controlled crossover study found indications that very high doses of vitamin B6 may produce beneficial effects in the treatment of autism. It has been suggested that combining magnesium with vitamin B6 could offer additional benefits, such as reducing side effects or allowing a reduced dose of the vitamin. Further research is needed. Autism should be treated by a qualified healthcare provider.
Attention deficit hyperactivity disorder
ADHD is characterized by attention deficit, impulsivity, and sometimes over activity ("hyperactivity"). ADHD begins in childhood and often persists into adulthood. The exact etiology is unknown; genetics plays a role, but major etiologic contributors also include adverse responses to food additives, intolerances to foods and sensitivities to environmental chemicals, molds, and fungi. Research suggests that nutrient deficiencies are common in ADHD; but when individually managed with pyridoxine supplementation alone or in combination with other vitamins and minerals, dietary modification, detoxification and other features of a wholistic/integrative program of management can ameliorate ADHD symptoms helping the ADHD subject lead a normal and productive life.
Preliminary research suggests that children with severe asthma may have inadequate pyridoxine status. A double-blind study of 76 children with asthma found significant benefit from vitamin B6 after the second month of usage. Children in the vitamin B6 group were able to reduce their doses of asthma medication (bronchodilators and steroids). However, the dosages of B6 used in these studies were quite high, in the range of 200 to 300 mg daily. Because of the risk of nerve injury, it is not advisable to take this much B6 without medical supervision.