• Nutrient and energy metabolism
• Immune function
• Connective tissue formation
• Healthy hair, skin nails and bones
Immunoderm contains zinc, which is an essential trace element in the body. Even though excess of zinc cannot be stored in the body, ingestion of zinc on daily basis is still needed in order to have a proper growth, maintain immune function, metabolize nutrients, form connective tissues.
Zinc (10 mg)
Dicalcium phosphate, magnesium stearate, silicon dioxide, hypromellose, microcrystalline cellulose.
*2X stronger than HerbalGenn Zinc 5 mg
Common Cold Formula is composition of traditional herbs used as remedies from ancient times. The active ingredients consists of Garlic (Allium Sativum) bulb, Echinacea puperea dry extract, herb top (3:1) and Vitamin C (Ascorbic acid). Echinacea species are native to North America and were used as traditional herbal remedies by the Great Plains Indian tribes. Later, settlers followed the Indians’ example and began using Echinacea for medicinal purposes as well. For a time, Echinacea enjoyed official status as a result of being listed in the US National Formulary from 1916-1950. However, use of Echinacea fell out of favor in the United States with the discovery of antibiotics. But now, people are becoming interested in Echinacea again because some antibiotics don’t work as well as they used to against certain bacteria.
Biogenique Structurally Active-Orthogenic (SAO) technology
SAO technology of Biogenique produces the combined effect of three different active ingredients as one unique effective formula. Echinacea has good anti-viral, anti-bacterial and anti-fungal property; Garlic is a good natural anti-biotic and vitamin C is antioxidant. SAO technology establishes a higher caliber of science for better quality research and formulation. It makes sure that the compounds are delivered on their potential to create effectiveness. Garlic contains a chemical called allicin which is unstable and changes into different chemical rather quickly. This allicin makes garlic smell. But the SAO technology of Biogenique prepares the odorless Common Cold Formula from garlic without destroying the medicinal properties of garlic. The final product after process is completely effective and has enteric coating so that it dissolves directly in the intestines and not in the stomach. The SAO technology in Echinacea stimulates the overall activity of the cells responsible for fighting all kinds of infection. It also inhibits an enzyme secreted by bacteria to help them gain excess to healthy cells. Unlike antibiotics, which directly attack bacteria, Echinacea makes its own immune cells more efficient at attacking bacteria, viruses and abnormal cells, including cancer cells. Our scientific research has proven that Echinacea stimulates phagocytosis, because of which foreign bodies that put our bodies at risk are destroyed by white blood cells and lymphocytes.
Echinacea activates chemicals in the body that decrease inflammation, which might reduce cold and flu symptoms. The herb significantly improves the body’s immunity and thus reduces the risk of contracting diseases. It increases the number and activity of immune system cells including anti-tumor cells, promotes T-cell activation, stimulates new tissue growth for wound healing and reduces inflammation in arthritis and inflammatory skin conditions. It also seems to contain some chemicals that can attack yeast and other kinds of fungi directly.
Garlic can kill certain bacteria such as E. coli, antibiotic-resistant Staphylococcus aureus, and Salmonella enteritidis. It is also used for fighting stress and fatigue, and maintaining healthy liver function. Preliminary research suggests garlic might reduce the frequency and number of colds when taken for prevention
Ascorbic acid (Vitamin C) functions:
Scientific studies generally suggest that people living in extreme climates or under extraordinary conditions, including soldiers in subarctic exercises, skiers, and marathon runners, vitamin C significantly reduced the risk of developing colds, by approximately 50%. Ascorbic acid is essential to perform important functions in the body, even small amounts of vitamin C can protect indispensable molecules in the body, such as proteins, lipids (fats), carbohydrates from damage by free radicals.
Upper respiratory tract infections: treatment and prevention
Echinacea is frequently recommended to reduce the duration and severity of upper respiratory tract infections (URIs) or the "common cold." However, the results of scientific studies are mixed. Studies even report that echinacea may help prevent upper respiratory tract infection in children with cold symptoms, but rash has also been associated with echinacea use in children, and the risks may outweigh the potential benefits. Additional research is needed in this area.
Role in Immunity
Echinacea has been studied alone and in combination preparations for immune system stimulation. Vitamin C affects several components of the human immune system; for example, vitamin C has been shown to stimulate both the production and function of leukocytes (white blood cells), especially neutrophils, lymphocytes, and phagocytes. Neutrophils, which attack foreign bacteria and viruses, seem to be the primary cell type stimulated by vitamin C. Additionally, several studies have shown that supplemental vitamin C increases serum levels of antibodies and C1q complement proteins in guinea pigs, which—like humans—cannot synthesize vitamin C and hence depend on dietary vitamin C. Vitamin C may also protect the integrity of immune cells. Phagocytic leukocytes also produce and release cytokines which have antiviral activity. It is widely thought by the general public that vitamin C boosts the function of the immune system, and accordingly, may protect against viral infections and perhaps other diseases. While some studies suggest the biological plausibility of vitamin C as an immune enhancer, human studies published to date are conflicting. Further, controlled clinical trials of appropriate statistical power would be necessary to determine if supplemental Echinacea along with vitamin C boosts the immune system.
Whether or not echinacea helps prevent or treat the common cold remains under debate. Some studies have shown that the herb can make you feel better faster. Others suggest that echinacea has no impact on a cold at all. Several clinical trials have shown that people who take echinacea as soon as they feel sick reduce the severity of their cold and have fewer symptoms than those who do not take the herb. One study of 95 people with early symptoms of cold and flu (such as runny nose, scratchy throat, and fever) found that those who drank several cups of echinacea tea every day for 5 days felt better sooner than those who drank tea without echinacea. A review of 14 clinical trials found that echinacea reduced the odds of developing a cold by 58% and the duration of a cold by 1 - 4 days. However, some experts dispute these findings claiming that there were several weaknesses in the analyses. Echinacea preparations tested in clinical trials differ greatly. It is important to choose a high quality echinacea supplement. Talk to your health care provider for recommendations.
By improving the body’s immunity, Echinacea puperea extracts keep the person healthy and at lower risk to even serious illnesses like cancer. Regular intake of this herb improves the response of our body’s cells in combating cancer cells. It has been found that the production of interferon is enhanced by this herb. This and other products such as Tumor Necrosis Factor, that are more actively produced when the herb is consumed, help fight off cancerous cells.
• Avoid with known allergy or hypersensitivity to Echinacea or its constituents; use caution if you are allergic to plants of the Daisy family.
• Individuals with asthma may be predisposed to allergic reactions to Echinacea. If symptoms persist or worsen, consult a health care practitioner.
• If you have an autoimmune disorder or progressive systemic disease such as tuberculosis, collagenosis, multiple sclerosis, AIDS and/or HIV infection or you are taking immunosuppressant’s, consult a health care practitioner prior to use.
• Although not enough research has been done to determine echinacea's safety for pregnancy or breastfeeding, it's advisable to avoid use during pregnancy or breastfeeding until more conclusive studies are conducted.
Interactions you should know about
• Caffeine interacts with ECHINACEA
The body breaks down caffeine to get rid of it. Echinacea might decrease how quickly the body breaks down caffeine. Taking Echinacea along with caffeine might cause too much caffeine in the bloodstream and increase the risk of side effects. Common side effects include jitteriness, headache, and fast heartbeat.
• Medications that decrease the immune system
(Immunosuppressants) interacts with ECHINACEA
Echinacea can increase the immune system. Taking Echinacea along with some medications that decrease the immune system might decrease the effectiveness of medications that decrease the immune system. Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
• Isoniazid (Nydrazid, INH) interacts with GARLIC
Garlic might reduce how much isoniazid (Nydrazid, INH) the body absorbs. This might decrease how well isoniazid (Nydrazid, INH) works. Don't take garlic if you take isoniazid (Nydrazid, INH).• Birth control pills (Contraceptive drugs) interacts with GARLIC Some birth control pills contain estrogen. The body breaks down the estrogen in birth control pills to get rid of it. Garlic might increase the breakdown of estrogen. Taking garlic along with birth control pills might decrease the effectiveness of birth control pills. If you take birth control pills along with garlic, use an additional form of birth control such as a condom.
Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.
I)Efficacy and safety of Echinaforce® in respiratory tract infections.
Allergy Clinic, Hochwangstr. 3, 7302 Landquart, Switzerland. firstname.lastname@example.org
Echinaforce® is the standardised extract of Echinacea purpurea from Bioforce, Switzerland. Recent studies show immunomodulation and broad antiviral effects against respiratory tract viruses. Haemagglutinin and Neuraminidase are blocked. In contrast to Oseltamivir no resistance is caused by Echinaforce®. A randomised, double-blind, placebo-controlled study over four months confirms that Echinaforce® supports the immune resistance and acts directly against a series of viruses. Echinaforce® is efficacious and safe in respiratory tract infections for long-term and short-term prevention as well as for acute treatment.
II)Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial.
Common Cold Centre and Healthcare, Cardiff University, Cardiff CF10 3XQ, UK.
Objective. To investigate the safety (risk) and efficacy (benefit) of Echinacea purpurea extract in the prevention of common cold episodes in a large population over a 4-month period. Methods. 755 healthy subjects were allocated to receive either an alcohol extract from freshly harvested E. purpurea (95% herba and 5% root) or placebo. Participants were required to record adverse events and to rate cold-related issues in a diary throughout the investigation period. Nasal secretions were sampled at acute colds and screened for viruses. Results. A total of 293 adverse events occurred with Echinacea and 306 with placebo treatment. Nine and 10% of participants experienced adverse events, which were at least possibly related to the study drug (adverse drug reactions). Thus, the safety of Echinacea was noninferior to placebo. Echinacea reduced the total number of cold episodes, cumulated episode days within the group, and pain-killer medicated episodes. Echinacea inhibited virally confirmed colds and especially prevented enveloped virus infections (P < 0.05). Echinacea showed maximal effects on recurrent infections, and preventive effects increased with therapy compliance and adherence to the protocol. Conclusions. Compliant prophylactic intake of E. purpurea over a 4-month period appeared to provide a positive risk to benefit ratio.
III)Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis.
Department of Nutrition, Hungkuang University, 34 Chung-Chie Road, Shalu, Taichung 43302, Taiwan.
Echinacea is a top-selling herbal supplement that acts as immunostimulant. It has been used to treat common cold, coughs, bronchitis and upper respiratory infections. It is also a popular product used in anticancer therapy. The cytotoxic effects of Echinacea on cancer cells are still not clear. The aims of this study were to provide a preliminary validation of the effects of 50% aqueous ethanol extract of Echinacea purpurea flowers and its major compound, cichoric acid, on human colon cancer cells Caco-2 and HCT-116.
MATERIALS AND METHODS:
The cytotoxic effects of Echinace flower extracts and cichoric acid on cell viability, telomerase activity, DNA fragmentation, β-catenin, caspase-9, and cleavage of poly-ADP-ribose polymerase (PARP) of human colon cancer cell were examined.
The results showed a significant inhibition of proliferation in E. purpurea flower extract and cichoric acid in a dose- and time-dependent manner. Cichoric acid treatment decreased telomerase activity in HCT-116 cells. Moreover, cichoric acid effectively induced apoptosis in colon cancer cells, which were characterized by DNA fragmentation, activation of caspase-9, cleavage of PARP and downregulation of β-catenin.
Our data indicate that cichoric acid has a strong growth-inhibitory effect against colon cancer cells, presumably resulting from the reduced telomerase activity and the induction of apoptosis. The exact mechanism of action should still be determined in future studies. Overall, the effects of 50% aqueous ethanol extract of E. purpurea flowers and cichoric acid may have provided in vitro evidence for the use as chemotherapeutic agents.
IV) Immune-enhancing role of vitamin C and zinc and effect on clinical conditions.
Bayer Consumer Care Ltd., Basel, Switzerland. email@example.com
Vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress. Supplementation of vitamin C was found to improve components of the human immune system such as antimicrobial and natural killer cell activities, lymphocyte proliferation, chemotaxis, and delayed-type hypersensitivity. Vitamin C contributes to maintaining the redox integrity of cells and thereby protects them against reactive oxygen species generated during the respiratory burst and in the inflammatory response. Likewise, zinc undernutrition or deficiency was shown to impair cellular mediators of innate immunity such as phagocytosis, natural killer cell activity, and the generation of oxidative burst. Therefore, both nutrients play important roles in immune function and the modulation of host resistance to infectious agents, reducing the risk, severity, and duration of infectious diseases. This is of special importance in populations in which insufficient intake of these nutrients is prevalent. In the developing world, this is the case in low- and middle-income countries, but also in subpopulations in industrialized countries, e.g. in the elderly. A large number of randomized controlled intervention trials with intakes of up to 1 g of vitamin C and up to 30 mg of zinc are available. These trials document that adequate intakes of vitamin C and zinc ameliorate symptoms and shorten the duration of respiratory tract infections including the common cold. Furthermore, vitamin C and zinc reduce the incidence and improve the outcome of pneumonia, malaria, and diarrhea infections, especially in children in developing countries.